U.S. Patent Application No. 20090191156
Inventor: Harold Brem and Marjana Tomic-Canic
July 30, 2009
This patent involves the use of granulocyte macrophage colony stimulating factor (GM-CSF) as a regenerative therapy for healing chronic wounds. One of the major biological roles of GM-CSF that has important implication on wound healing is its ability to promote migration of keratinocytes to wound sites. Moreover, GM-CSF enhances fibroblast proliferation as well as both the quantity and quality of collagen. This invention has demonstrated the reversal of skin impairment in multiple animal models when GM-CSF was incorporated into a delivery vehicle and diabetic skin wounds were treated with an effective amount of GM-CSF over an effective time period. The treatment resulted not only in induced collagen deposition but also promoted its proper alignment. GM-CSF is now one of the standard growth-factor therapies used to treat chronic wounds at the Winthrop-University Hospital Wound Healing Center.
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