Dr. Harold Brem Bibliography

Below is a partial bibliography of Dr. Brem's publications. Click on the following link for a selected list of some of our wound research team's most significant publications, along with links to PDF

versions of the complete articles.

Original Reports

  1. Brem H. A murine brain tumor model for the study of angiogenesis. Surgical Forum 1986; 37:502
  2. Brem H, Guttman FM, Laberge JM, Doody D. Congenital anal fistula with normal anus. Journal of Pediatric Surgery. 1989; 24:183-185.
  3. Verrier ED, Crombleholm TM, Saver L, Longaker M, Langer JC, Flake AW, Dae M, Brem H, Harrison MR. Neonatal model of heterotopic cardiac transplantation in swine. Journal of Thoracic and Cardiovascular Surgery 1989; 98:127-135.
  4. Brem H, Beaver BL, Colombani PM, Zinreich J, Carson BS, Haller A Jr. Neonatal diagnosis of an anterior meningocele in the presence of congenital anal stenosis and partial sacral agenesis. Journal of Pediatric Surgery 1989; 24:1076-1078.
  5. Brem H, Gibbons G, Cobb G, Edgin R, Ellison E, Carey L. The use of endoscopy to treat bronchobiliary fistula resulting from choledocholithiasis. Gastroenterology 1990; 98:490-492.
  6. Ingber D, Fujita T, Kishimoto S, Sudo K, Kanamaru T, Brem H, Folkman J. Synthetic analogs of fumagillin that inhibits angiogenesis and suppress tumor growth. Nature 1990; 348:555-557.
  7. Brem H, Ingber D, Blood CH, Bradley D, Urioste S, Folkman J. Suppression of tumor metastasis by angiogenesis inhibition. Surgical Forum 1991; 42:439.
  8. Brem H, Shing Y, Watanabe H, Tamavokopoulis G, Marikovsky M, Voght P, Klagsbrun M, Grosfeld J, Ericksson E, Folkman J. Temporal expression of basic fibroblast growth factor during wound healing. Surgical Forum 1992; 43:664.
  9. Brem H, Folkman J. Analysis of experimental antiangiogenic therapy. Journal of Pediatric Surgery 1993; 28:445-450.
  10. Takayamiya Y, Friedlander R, Brem H, Malick A, Martuza R. Inhibition of angiogenesis and growth of human nerve-sheath tumors by AGM-1470. Journal of Neurosurgery 1993; 78:470.
  11. Brem H, Gresser I, Grosfeld J, Folkman J. The combination of antiangiogenic agents to inhibit primary tumor growth and metastasis. Journal of Pediatric Surgery 1993; 28:1253.
  12. Schoof D, Obando A, Cusack J, Goedegbuure P, Brem H, Eberlein T. The influence of the angiogenesis inhibitor AGM-1470 on immune system status and tumor growth in vitro. International Journal of Cancer 1993; 55:630.
  13. Takayamiya Y, Brem H, Ojeifo J, Mineta T, Martuza R. AGM-1470 inhibits the growth of human glioblastoma cells in vitro and in vivo. Neurosurgery 1994; 34:869.
  14. Brem H, Gotto F, Budson A, Saunders L, Folkman J. Minimal drug resistance after prolonged antiangiogenic therapy with AGM-1470. Surgical Forum 1994; 45:674.
  15. Teicher BA, Holden SA, Ara G, Sotomayor EA, Huang ZD, Chen YN, Brem H. Potentiation of cytotoxic cancer therapies by the TNP-470 alone and with other antiangiogenic agents. International Journal of Cancer 1994; 57:920.
  16. O’ Reilly M, Brem H, and Folkman J. Treatment of murine hemangioendotheliomas with the angiogenesis inhibitor AGM-1470. Journal of Pediatric Surgery 1995; 30:325.
  17. Brem H, Ehrlich HP, Tsakayannis D, Folkman J. The modulation of angiogenesis during wound healing: Studies with the angiogenesis inhibitor TNP-470: Surgical Forum 1997; 48: 714.
  18. Kirsner R, Falanga V, Fivenson D, Thibodeaux K, Cavorsi J, de la Pava D, Brem H, Golomb C.  Clinical experience with a human skin equivalent for the treatment of venous leg ulcers: process and outcomes.  Wounds 1999; 11:137-44.
  19. Brem H and Kirsner R. Use of Graftskin in the treatment of pressure ulcers and acute wounds. Wounds 2000; 12:72-77.
  20. Rosser JC, Prosst RL, Rodas EB, Rosser LE, Murayama M, Brem H. Evaluation of the effectiveness of portable low-bandwidth telemedical applications for postoperative follow-up: Initial results. Journal of the American College of Surgeons  2000; 191:196-203.
  21. Brem H, Balledux J, Bloom T, Kerstein M, Hollier L. Healing of diabetic ulcers and pressure ulcers with human skin equivalent: A new paradigm in wound healing. Archives of Surgery 2000; 135:627-634.
  22. Brem H, Balledux J, Sukkarieh T, Falanga V. Healing of venous ulcers of long duration with a bilayered living skin substitute: Results from a general surgery and dermatology department. Dermatologic Surgery. 2001; 27:915-919.
  23. Visco DC, Shalley T, Wren SJ, Flynn JP, Brem H, Kerstein MD, Fitzpatrick JJ. Use of telehealth for chronic wound care: A case study. Journal of Wound Ostomy Continence Nursing 2001; 28:89-95.
  24. Kerstein, MD, Brem H, Giovino KB, Sabolinski M. Development of a severity scale for evaluating the need for Graftskin in nonhealing venous ulcers. Advances in Skin & Wound Care. 2002; 15:66-71.
  25. Brem H, Nelson J, Nierman, D. Treatment of pressure ulcers in the intensive care unit. Critical Care Clinics of North America, 2002; 18:1-1.
  26. Brem H, Nierman DM, Nelson JE. Pressure ulcers in the chronically critically ill patient. Critical Care Clinics of North America, 2002; 18:683-94.
  27. Brem H, Young J, Tomic-Canic M, Isaacs C, Ehrlich HP. Clinical efficacy and mechanism of bilayered living human skin equivalent in the treatment of diabetic foot ulcers. Surgery Technology International.  2003; 11:23-31.
  28. Brem H, Jacobs T, Vileikyte L, Weinberger S, Gibber M, Boulton A. Wound healing protocols for diabetic foot and pressure ulcers. Surgery Technology International. 2003; 11: 85-96.
  29. Freedman G, Cean C, Duron V, Tarnovskaya A, and Brem H. Pathogenesis and treatment of pain in patients with chronic wounds. Surgery Technology International. 2003; 11:168-182.
  30. Brem H, Gill K, Tarnovskaya A, Ehrlich HP, Carasa M, Weinberger S, Baskin-Bey E, Tomic-Canic M, Vladeck B. Healing of elderly patients with diabetic foot ulcers, venous stasis ulcers, and pressure ulcers. Surgery Technology International. 2003; 11:161-167.
  31. Peppa M, Brem H, Zhang J, Cai W, Vlassara H. Adverse effects of dietary glycotoxins on wound healing in genetically diabetic mice. Diabetes.  2003;52:2805-13.
  32. Brem H, Sheehan P, Boulton AJM. Protocol for the treatment of diabetic foot ulcers. American Journal of Surgery. 2004; 187:1S-10S.
  33. Brem H, Lyder C. Protocol for successful treatment of pressure ulcers. American Journal of Surgery. 2004; 188:9-17.
  34. Freedman G, Entero H, Brem H. Practical treatment of pain in patients with chronic wounds: a pathogenesis-guided management. American Journal of Surgery. 2004; 188:31-5.
  35. Tomic-Canic M, Brem H. Gene array technology and pathogenesis of chronic wounds. American Journal of Surgery. 2004; 188:67-72.
  36. Wallenstein S, Brem H.Statistical analysis of wound healing rates for pressure ulcers. American Journal of Surgery. 2004;188:73-8.
  37. Brem H, Kirsner RS, Falanga V. Protocol for the successful treatment of venous ulcers. American Journal of Surgery. 2004; 188:1-8.
  38. Lee B, Vouthounis C, Stojadinovic O, Brem H, Im MJ, Tomic-Canic M. From an enhanceosome to a repressosome: molecular antagonism between glucocorticoids and EGF leads to inhibition of wound healing. Journal of Molecular Biology. 2005; 345:1083-1097.
  39. Jho SH, Vouthounis C, Lee B, Stojadinovic O, Brem H, Im MJ, Merchant A, Tomic-Canic M. The book of opposites: The role of the nuclear receptor co-regulator proteins in negative regulation by retinoic acid and thyroid hormone receptors. Journal of Investigative Dermatology. 2005; 124:1034-43.
  40. Stojadinovic O, Brem H, Vouthounis C, Lee B, Fallon J, Stallcup M, Merchant A, Galiano RD, Tomic-Canic M. Molecular pathogenesis of chronic wounds: The role of β-catenin and c-myc in the inhibition of epithelialization and wound healing. American Journal of Pathology. 2005; 167:59-69.
  41. Brem H, Sheehan P, Rosenberg HJ, Schneider JS, Boulton AJ. Evidence-based protocol for diabetic foot ulcers. Plastic and Reconstructive Surgery. 2006; 117(Suppl.):193S-209S.
  42. Peppa M, Brem H, Cai W, Zhang JG, Basgen J, Li Z, Vlassara H, Uribarri J. Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711). American Journal of Nephrology. 2006; 26:430-436.
  43. Koo K, Brem H, Lebwohl M. Pyoderma gangrenosum versus chronic venous ulceration: comparison of diagnostic features. Journal of Cutaneous Medicine and Surgery. 2006; 10:26-30.
  44. Stojadinovic O, Lee B, Vouthounis C, Vukelic S, Pastar I, Blumenberg M, Brem H, Tomic-Canic M. Novel genomic effects of glucocorticoids in epidermal Keratinocytes: inhibition of apoptosis, interferon-gamma pathway, and wound healing along with promotion of terminal differentiation. Journal of Biological Chemistry. 2007; 282:4021-4034.
  45. Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. Journal of Clinical Investigation. 2007; 117:1219-1222.
  46. Brem H, Tomic-Canic M, Entero H, Hanflik AM, Wang VM, Fallon JT, Ehrlich HP. The synergism of age and db/db genotype impairs wound healing. Experimental Gerontology. 2007; 42:523-531.
  47. Brem H, Stojadinovic O, Diegelmann R, Entero H, Lee B, Pastar I, Golinko M, Rosenberg H, Tomic-Canic M. Molecular markers in patients with chronic wounds to guide surgical debridement. Molecular Medicine. 2007; 13:30-39.
  48. Stojadinovic O, Pastar I, Vukelic S, Mahoney MG, Brennan D, Krzyzanowska A, Golinko MS, Brem H, Tomic-Canic M. Deregulation of keratinocyte differentiation and activation pathways are a hallmark of pathogenesis of chronic wounds. Journal of Cell and Molecular Medicine. 2008; 12:2675-2690.
  49. Harsha A, Stojadinovic O, Brem H, Sehara-Fujisawa A, Wewer U, Loomis CA, Blobel CP, Tomic-Canic M. ADAM12: a potential target for the treatment of chronic wounds. Journal of Molecular Medicine. 2008; 86: 961-969.
  50. Steed DL, Attinger C, Brem H, Colaizzi T, Crossland M, et. al. Guidelines for the prevention of diabetic ulcers. Wound Repair and Regeneration. 2008; 16:169-174.
  51. Franz MG, Robson MC, Steed DL, Barbul A, Brem H, Cooper DM, Leaper D, Milner SM, Payne WG, Wachtel TL, Wiersema-Bryant L. Guidelines to aid healing of acute wounds by decreasing impediments of healing. Wound Repair and Regeneration. 2008; 16:723-48.
  52. Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic Canic M. Growth factors and cytokines in wound healing. Wound Repair Regeneration. 2008; 16:585-601.
  53. Falanga V, Brem H, Ennis WJ, Wolcott R, Gould LJ, Ayello EA. Maintenance debridement in the treatment of difficult-to-heal chronic wounds.  Ostomy Wound Management.  2008; Suppl. S: 2-13.
  54. Tomic-Canic M, Ayello EA, Stojadinovic O, Golinko MS, Brem, H. Using gene transcription patterns (bar coding scans) to guide wound debridement and healing. Advanced Skin Wound Care.  2008; 21:487-92.
  55. Flattau A, Schiffman J, Lowy F, Brem H. Antibiotic-resistant gram-negative bacteria in deep tissue cultures. International Wound Journal. 2008; 5: 599-600.
  56. Golinko MS, Cox D, Martinez L; Joffe R, Chandrasekaran E, Brem H. Operative debridement of diabetic foot ulcers (written paper and video). Journal of the American College of Surgeons. 2008; 207:e1-6.
  57. Brem H, Golinko MS, Stojadinovic O, Kodra A, Diegelmann RF, Vukelic S, Entero H, Coppock DL, Tomic-Canic M. Primary cultured fibroblasts derived from patients with chronic wounds: A methodology to produce human cell lines and test putative growth factor therapy such as GMCSF. Journal of Translational Research. 2008; 6:75.
  58. Rennert R, Golinko MS, Kaplan D, Flattau A, Brem H. Standardization of wound photography utilizing the Wound Electronic Medical Record. Advances in Skin & Wound Care 2009; 22:32-38.
  59. Bao P, Kodra A, Tomic- Canic M, Golinko MS, Ehrlich HP, Brem H. The role of vascular endothelial growth factor in wound healing. Journal of Surgical Research. 2009; 153:347-358.
  60. Rennert R, Golinko M, Yan A, Flattau A, Tomic-Canic M, Brem H. Developing and evaluating outcomes of an evidence-based protocol for the treatment of osteomyelitis in stage IV pressure ulcers: A literature and Wound Electronic Medical Record database review. Ostomy Wound Management. 2009; 55:42-53.
  61. Schiffman J, Golinko MS, Yan A, Flattau A, Tomic-Canic M, Brem, H. Operative debridement of pressure ulcers. World Journal of Surgery. 2009; 33:1396-1402.
  62. Golinko MS, Clark S, Rennert R, Flattau A, Brem H. Wound emergencies: The importance of assessment, documentation and early treatment using a Wound Electronic Medical Record. Ostomy Wound Management.   2009; 55:54-61.
  63. Golinko MS, JoffeR, DeVinck D, ChandrasekaranE, Stojadinovic O, Barrientos S, Vukelic, S, Tomic- Canic M, Brem H. Surgical pathology to describe the clinical margin of debridement of chronic wounds using a Wound Electronic Medical Record. Journal of the American College of Surgeons. 2009; 209:254-260.
  64. Altchek A, Hanflik A, Deligdisch L, Brem H. Cultured bilayered skin allograft for vaginal construction. Journal of Pediatric Adolescent Gynecol 2010; 23:e5-8. Epub 2009 Sep 3.
  65. Brem H, Kodra A, Golinko MS, Entero H, Stojadinovic O, Wang V, Sheahan C, Weinberg A, Woo S, Ehrlich HP, Tomic-Canic M. Mechanism of sustained release of vascular endothelial growth factor in accelerating experimental diabetic healing. Journal of Investigative Dermatology 2009; 129:2275-2287.
  66. Golinko MS, Margolis DJ, Tal A, Hoffstad O, Boulton AJ, Brem H. Preliminary development of a diabetic foot ulcer database from a Wound Electronic Medical Record: A tool to decrease limb amputations. Wound Repair Regeneration 2009; 17:-657-65.
  67. Pastar I, Stojadinovic O, Krzyzanowska A, Barriento S, Stuelten C, Zimmerman K, Blumenberg M, Brem H, Tomic-Canic M. Attenuation of the transforming growth factor beta-signaling pathway in chronic venous ulcers. Molecular Medicine. 2010; 16:92-101.
  68. Brem H, Maggi J, Nierman D, Rolnitzky L, Bell D, Rennert R, Golinko M, Yan A, Lyder C, Vladeck B. High cost of stage IV pressure ulcers. American Journal of Surgery. 2010; 200:473-477.
  69. Vukelic S, Stojadinovic O, Pastar I, Rabach M, Krzyzanowska A, Lebrun E, Davis SC, Resnik S, Brem H, Tomic-Canic M. Cortisol synthesis in epidermis is induced by IL-1 and tissue injury. J Biol Chem. 2011; 286:10265-75.

Reviews, Books, and Chapters

  1. Brem H, Tamargo RJ, Guerin C, Brem SS, Brem H: Brain tumor angiogenesis. In: Advances in Neuro-oncology. Kornblith PL and Walker MD, eds.  Futura Publishing Co.; 1988; 89-108.
  2. Ingber D, Fujita T, Kishimoto S, Sudo K, Kanamaru T, Brem H, Folkman J:  Synthetic analogs of fumagillin that inhibits angiogenesis and suppress tumor growth. Selected in abstract from The Yearbook of Surgery, Schwartz S, Jonasson O, Peacock EE, Shires GT, Spencer GT, Thompson JC, eds 1992.
  3. Folkman J, Brem H: Angiogenesis and inflammation. In: Inflammation: Basic Principles and Clinical Correlates, 2nd Edition, Gallin JL, Goldstein IM, Snyderman R, eds., Raven Press, New York, NY: 1992; 821-39.
  4. Brem H, Klagsbrun M: The role of fibroblast growth factors and related oncogenes in tumor growth. In: Oncogenes and Tumor Supressor Genes in Human Malignancies.  Benz CC, Liu ET, eds. Kluwer Academic Publishers: 1993; 211-31.
  5. Brem H, Tamavokopulis G, Tsakayannis D, Gresser I, Budson A, Folkman J:  Regulation of blood vessel growth in tumors and wounds. In: Angiogenesis, Molecular Biology, Clinical Aspects. Marajoudakis ME, Gullino PM, Lelkes PI (eds.) Plenum Press Publishers, 1994; 335-336.
  6. Brem H, Folkman J: Angiogenesis and basic fibroblast growth factor during wound healing. In: Bone Formation and Repair.  Brighton CT, Friedlaender GE, Lane JM (eds.)  American Academy of Orthopedic Surgeons Publishers. 1994; 213, 222-240.
  7. Rosser JC, Latifi R, and Brem H.  Pathophysiology of esophageal reflux.  In: R.C. Merrell, Editor.  Laparoscopic Surgery: A Colloquium. Springer Verlag, New York.  1999; 103-114.
  8. Rosser JC, and Brem H. Technique of laparoscopic Nissen fundoplication.  In: R.C. Merrell, Editor.  Laparoscopic Surgery: A Colloquium.  Springer Verlag, New York, 1999; 115-125
  9. Latifi R, Brem H, and Rosser JC.   In search of a role for laparoscopic inguinal hernia repair.  In: R.C. Merrell, Ed.  Laparoscopic Surgery: A Colloquium Springer Verlag, New York, 1999; 167-179.
  10. Latifi R, Rosser JC, and Brem H.  Anatomy and clinical outcomes in surgery for esophageal reflux.  In: R.C. Merrell, Ed:  Laparoscopic Surgery: a Colloquium Springer Verlag, New York, 1999; 95-102.
  11. Mineta GL, Falanga V, Brem H. Current and investigative use of Graftskin in wound care: Questions and answers. Wounds 2000;12:47A-49A.
  12. Falanga V, Brem H. Wound bed preparation for optimal use of advanced therapeutic products.  In: Falanga V, Ed.  Cutaneous Wound Healing.  Boston University Press, 2001; 457-468.
  13. Brem H. Specific paradigm for wound bed preparation in chronic wounds.  In Cherry GW, Harding KG, Ryan TJ, eds.  Wound Bed Preparation.  The Royal Society of Medicine Press Ltd.  University of Oxford, UK. 2001; 33-39.
  14. Willis A, Gibber M, Moore S, Brem H. Sickle cell disease and leg ulcers: Pathogenesis, complications, assessment, and treatment.  In Ayello EA, Baranoski S, eds. Wound Care Essentials.   Springhouse. Hagerstown, 2003.
  15. Hanflik. A, Golinko, M, Doft, M, Cain, C, Flattau, A, Brem, H. Operative Debridements of Chronic Wounds in Geriatric Persons. Eds. Jeffrey H. Silverstein, G. Alec Rooke,, J.G. Reves, Charles H. McLeskey. In Geriatric Anesthesia, 2nd Edition. New York. Springer, 2007.
  16. Treadwell TA, Willis AC,  Brem H. Sickle cell ulcers. In Ayello EA, Barnoski S, eds. Wound Care Essentials: Practice Principles, Second Edition. Lippincott Williams & Wilkins, 2008; 363-372.
  17. Maggi J, Brem H. The future of CACS in wound healing. Archives Surgery 2010; 145:266.
  18. Zimmerman K, Stojadinovic O, Lebrun E, Tomic-Canic M, Brem H. Cellular and Molecular Mechanism of Chronic Wounds Advances in Wound Care 2010, Volume 1:165-176.
  19. Maggi J, Ragupathi M, Tomic-Canic M, Brem H. Age and Impaired Healing Potential, Advances in Wound Care 2010, Volume 1: 177-186.

Media Resource Educational Material

CD ROMs edited by H. Brem, MD and written by James C. Rosser, MD

  1. 1998    Laparoscopic Inguinal Hernia – Surgical Techniques
  2. 1998    Laparoscopic Inguinal Hernia – Patient Education
  3. 1998    Laparoscopic Cholecystectomy – Surgical Techniques
  4. 1998    Laparoscopic Cholecystectomy – Patient Education
  5. 1998    Laparoscopic Nissen Fundoplication – Surgical Techniques
  6. 1998    Laparoscopic Nissen Fundoplication – Patient Education

 Wound Healing Videos produced with senior author H. Brem

  1. 2008   American College of Surgeons – Surgical Techniques and the Importance of Wide Debridement in Diabetic Foot Ulcers, (American College of Surgeons)
  2. 2008   American College of Surgeons – Surgical Technique of Debridement for New Stage IV Pressure Ulcers, (American College of Surgeons)
  3. 2009   American College of Surgeons – Surgical Deep Tissue Debridement of Pressure Ulcers: Techniques of Wound and Bone Excision in the Presence of Osteomyelitis. (American College of Surgeons)
  4. 2009   American College of Surgeons- Surgical Technique Correlating the Molecular Basis of Non-healing Venous Ulcers (American College of Surgeons)
  5. 2009   American College of Surgeons- Surgical Debridement of a Diabetic Foot Ulcer with Osteomyelitis: Cellular Basis of Healing (American College of Surgeons)
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