A Radiation Wound Healed by Surgery, Growth Factors, Hyperbaric Oxygen and a Skin Graft
PN, a 64-year-old patient, had undergone cancer radiotherapy treatment which left him with a severe radiation wound to his left chest wall. The wound was not only causing him severe pain but had also developed a life-threatening infection. He had previously sought treatment at numerous other wound centers before finally being referred to Dr. Brem's team for treatment using our regenerative medicine approach. In addition to diabetes and obesity, PN also had a rare abnormal blood vessel disease called Osler-Weber-Rendu syndrome, which results in tiny blood vessel malformations. After an initial surgical cleaning of the wound (debridement), PN subsequently received another series of debridements followed by treatment with a growth factor called human recombinant granulocyte macrophage colony stimulating factor. In addition, he received daily hyperbaric therapy.
Although PN’s overall condition was very difficult to treat medically, under the expert direction of the team's hyperbaric oxygen therapy specialists, he was able to continue hyperbaric treatments while receiving transfusions for blood loss due to the tumor. In a relatively short time, the team's plastic surgeon was able to perform a skin graft on PN’s wound, which proved successful thanks to the targeted application of growth factor therapy to the area of necrosis as determined by PN’s pathology reports.
PN’s successful treatment is a true example of how personalized wound therapy, including multidisciplinary care combined with Dr. Brem's regenerative medicine approach, hyperbaric treatments and an expert surgical team, was able to heal a wound that had resisted treatment for an extended time.